Understanding the potential for widespread plague resistance in prairie dogs
Modeling host evolution in a dynamic metapopulation
Prairie dogs are keystone species of North America’s central grasslands, and have experienced dramatic population reductions over the past century due to sylvatic plague, a highly virulent disease introduced to North America ca. 1900. The APE lab is involved in building a novel host-resistance modeling framework to investigate the genetic, demographic and environmental conditions that promote or impede resistance to plague and other similar virulent pathogens in complex and dynamic ecosystems.…